Corticosteroid suppression of lymphocytic thyroid stimulator production.
نویسندگان
چکیده
منابع مشابه
Long-Acting Thyroid Stimulator
Highly purified bovine TSH (thyroid-stimulating hormone) was labelled with 125I by using very low concentrations of chloramine-T. Human thyroid membranes prepared by discontinuous sucrose-density-gradient centrifugation were homogeneous on examination by electron microscopy. Incubation of radioiodinated TSH with the membranes showed that radioactivity could be bound to the membranes. Under the ...
متن کاملInhibition of long-acting thyroid stimulator by thyroid particulate fractions.
The long-acting thyroid stimulator (LATS), found uniquely in the serum of patients with Graves' disease, is closely associated with the immunoglobulin G (IgG) proteins of serum and is removed from serum by antibody to human IgG (2, 3). Since some IgG molecules function as antibodies, it seems possible that LATS is also an antibody. This possibility would be strengthened if LATS could be demonst...
متن کاملLymphocytic choriomeningitis virus can persistently infect thyroid epithelial cells and perturb thyroid hormone production.
Although viral infection has been suspected as the cause of some thyroid disorders, there has been limited data to support this contention seriously. Now we report the first evidence that lymphocytic choriomeningitis virus can persist in the thyroid gland, particularly thyroid epithelial cells in which thyroglobulin (Tg) the precursor of thyroid hormone, is synthesized. Concomitant with the inf...
متن کاملNeonatal hyperthyroidism and long-acting thyroid stimulator protector.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may...
متن کاملEffects of long-acting thyroid stimulator (LATS) and LATS protector on human thyroid adenyl cyclase activity.
The long-acting thyroid stimulator (LATS) has been thought to be responsible for the hyperthyroidism of Graves's disease. It is detected by its effect on the mouse thyroid gland but cannot be found in all patients with hyperthyroidism. In an attempt to clarify the problem of LATS-negative hyperthyroidism, serum was obtained from untreated patients and its effect in vitro on human thyroid tissue...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1978
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)38255-8